3: microRNAs are required for Müller glia function (DicerCKO)

Deleting Dicer, the enzyme that generates mature microRNAs in Müller glia, leads to a disruption in the retinal architecture. Müller glia proliferate and migrate and do not function properly anymore. As a consequence, photoreceptors die and a phenotype that resembles retinitis pigmentosa can be observed over time. Wohl, S. G., Jorstad, N. L., Levine, E., and Reh, T.A., 2017: Müller glial microRNAs are required for the maintenance of glial homeostasis and retinal architecture. Nature Communications, 8(1):1603. DOI: 10.1038/s41467-017-01624